This presentation describes how Fluent's fluid flow and mixing experts create comprehensive mixing process reviews for bioreactors at the lab, pilot and production scales for our clients in the pharmaceutical and specialty chemical industries. Using fundamental theories of mixing and decades of accumulated experience, Fluent blends the best of fluid mixing engineering practices with state-of-the-art computational techniques to optimize performance of biochemical and chemical stirred tank reactors.

We will describe the type of fluid mixing engineering reviews that we design for our clients to deliver engineering value early in the project life cycle and identify the best use of computational fluid dynamics (CFD) simulations, thus minimizing longer-term project expenditure. Such reviews are extremely important for overall understanding of bioreactors at the different scales since the bioreactors must be properly designed to meet multiple design criteria such as liquid blending, gas dispersion, cell suspension, gas-liquid mass transfer, cell-liquid mass transfer, local turbulence, local shear rate, and bubble size distribution. The critical design criterion can change depending on reactor scale, agitation rate, gas rate, sparger design and impeller selection.

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